Methylcobalamin the most bio-available form of Vitamin B12, i. Further to this research has shown that it remains in the body for a longer period of time and at higher levels than cyanocobalamin, which means that your body is supplied with vitamin B12 for longer if you use methylcobalamin than if you use cyanocobalamin. Methylcobalamin is used primarily in your liver, brain and nervous system, in fact methylcobalamin is the specific form of B12 needed for nervous system health.
Because of methylcobalamin's importance in nervous system health, it is also an important nutrient for vision. Research has shown that methylcobalamin significantly improves visual accommodation, while cyanocobalamin appears to be ineffective. Visual accommodation is the ability to quickly shift your focus from something nearby to something further away - this is often impaired by activities such as staring at a computer screen for long periods of time.
The most well studied use of methylcobalamin has to do with sleep - although the exact mechanism of action is not yet clear, it is possible that methylcobalamin is needed for the synthesis of melatonin.
Research indicates that methylcobalamin can modulate melatonin secretion, enhance light-sensitivity, and normalise circadian rhythm your body's hour clock. It is the cheapest form of Vitamin B12, but once broken into the active forms, it is highly effective. People often ask which is better — the naturally occurring Methylcobalamin or the synthetic Cyanocobalamin? The jury is out to be honest : the body does indeed absorb Cyanocobalamin very well but Methylcobalamin is considered to be retained better and for longer.
What is known is that Methylcobalamin should be combined with Adenosylcobalamin for best results. NHS treats vitamin B12 deficiency with injections of vitamin B If your deficiency is more serious and you have symptoms of ill-health, a stronger dose of Vitamin B12 may be prescribed to be taken orally, in an IV drip or an intramuscular shot. Check your clinic is fully licenced to administer this treatment before progressing.
IV Boost is licenced to give Vitamin B12 injections or IV drips and we will only do this following a face-to-face consultation which establishes if this is both necessary and suitable.
To organise a consultation regarding our B12 shots or IV drips, contact our team today on In my practice I use different forms of Vitamin B In this article I explain some of the differences between cyanocobalamin, methylcobalamin, and hydroxocobalamin. It should not be given intravenously. Of all the forms of Vitamin B12 it is the least painful for the patient to inject. In this case, use a mixture of both methyl B12 and adenosyl B Some types of B12 are better than others, as you now understand.
Cyano B12 is an inactive, slightly toxic form of B It contains a cyanide molecule, which your body will have to remove through methylation, a reaction that requires methyl groups. Glutathione seems to be the agent performing the decyanation. Hydroxo B12 is an inactive form of B12 as well, but it is better than cyano B Remember to always monitor nitric oxide levels during administration. If you can make use of methyl or adenosyl B12, however, it is always the better route.
Adenosyl B12 and methyl B12 are the native forms of vitamin B12, bypassing several steps in the absorption cycle. Both of them absorb, retain and increase tissue concentration much better. As a result, they often produce clinical results far superior to what either cyano or hydroxy B12 can offer. Their use offers significant benefits and should be the first line of defense against conditions that may benefit from B Remember, these two forms of vitamin B12 inter-convert.
It exhibits distinct neuroprotective effects, improving nerve regeneration while bringing synaptic transmutations and diminished neurotransmitters back to normal levels. Unlike adenosyl B12, methyl B12 donates a valuable methyl group that further enhances your health unlike cyano, which steals one.
This is especially important for pernicious anemia patients or anyone suffering from high homocysteine levels. This donation of methyl groups may be the reason why methyl B12 is helpful in so many conditions.
Update: You can now order injectable B12 again. Get it here. Close Top Banner. Home » B12 » Vitamin B12 Forms. There are four forms of vitamin B12 you can take.
Which one is the best for you? And so, back to our question: Which type of B12 should you supplement with? Cyanocobalamin Also CN-Cbl, or Cyano B12 Cyano B12 is a cheap, synthetic, slightly-toxic, inactive form of B12 that is made with a cyanide donor and is used commercially.
Then why does cyano B12 even exist? Check out this paper from : If the indiscriminate dumping of industrial cyanide waste continues unchecked with the inherent risk of pollution of food and water supplies there may well come a time when more widespread chronic cyanide neurotoxicity occurs in the Western hemisphere from a dietary source in persons with a genetic or acquired error of cyanide or vitamin B12 metabolism.
Why can you even buy cyano B12 then? Not natural to mammals whatsoever. Methylcobalamin also Mecobalamin, MeCbl, MetCbl, MetB12, MeB12, or Methyl B12 Methylcobalamin as an endogenous coenzyme plays as important a role in transmethylation of methionine synthetase in the synthesis of methionine from homocysteine.
Oxford Biosciences. Is methyl B12 really so effective? What else? Also, remember we talked about B12 converting homocysteine to methionine?
On methyl B12 and sleep The science on methyl B12 and sleep is really promising. Vitamin B12 enhances the phase-response of circadian melatonin rhythm to a single bright light exposure in humans It makes sense, because the formation of melatonin requires a methyl group. Here is another interesting case: Two adolescent patients suffering from persistent sleep-wake schedule disorders appear to have responded to treatment with vitamin B12 methylcobalamin.
Treatment of persistent sleep-wake schedule disorders in adolescents with methylcobalamin vitamin B12 So, are you having issues with your sleep-wake schedule?
Any other benefits to methyl B12? Methyl B12 vs Cyano B12 Now, how does methylcobalamin compare to cyanocobalamin, the previous form we examined, when it comes to absorption rate and bio-availability? But careful: Suppressing nitric oxide could have adverse affects like elevated blood pressure, digestive disturbances, impotence, susceptibility to infection, even increased risk of cancer. But what about supplementing with adenosyl B12?
Not bad. Adenosyl B12 vs methyl B12 So, which one is better for you? Remember, the two inter-convert in the body. So, which is the best type of B12? This process is demanding and can be hampered in a range of conditions. As a result, we recommend this form to absolutely no one. And the best vitamin B12 forms are… Adenosyl B12 and methyl B12 are the native forms of vitamin B12, bypassing several steps in the absorption cycle.
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