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The role of nuclear localization signal in parvovirus life cycle. Download references. We thank the current and former members of our laboratories and collaborators for their contributions to this review article.
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Skip to main content. Search all BMC articles Search. Download PDF. Abstract Nuclear localization signals NLS are generally short peptides that act as a signal fragment that mediates the transport of proteins from the cytoplasm into the nucleus. Video Abstract. Nuclear export of proteins: The role of nuclear retention. Nuclear targeting in plants. Research over the past ten years has yielded information about the mechanism and some of the factors required for the specific uptake of certain proteins by the nucleus see, for example, … Expand.
Molecular trafficking across the nuclear pore complex. Identification of specific binding proteins for a nuclear location sequence. Nuclear import can be separated into distinct steps in vitro: Nuclear pore binding and translocation. Synthetic peptides as nuclear localization signals. Facilitated nuclear transport of histone H1 and other small nucleophilic proteins. Reconstitution of biochemically altered nuclear pores: Transport can be eliminated and restored.
Protein import through the nuclear pore complex is a multistep process. Interaction of a nuclear location signal with isolated nuclear envelopes and identification of signal-binding proteins by photoaffinity labeling. Nuclear protein migration involves two steps: Rapid binding at the nuclear envelope followed by slower translocation through nuclear pores.
Major nucleolar proteins shuttle between nucleus and cytoplasm. Functional organization of the nuclear envelope. This communication is regulated by the nuclear pores.
Each nuclear pore is a large complex of proteins that allows small molecules and ions to freely pass, or diffuse, into or out of the nucleus. Nuclear pores also allow necessary proteins to enter the nucleus from the cytoplasm if the proteins have special sequences that indicate they belong in the nucleus. These sequence tags are known as nuclear localization signals. Similarly, RNA transcribed in the nucleus and proteins that are destined to enter the cytoplasm have nuclear export sequences that tag them for release through the nuclear pores.
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